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Mathematical & Statistical Modelling of Cytokine Receptor Cross-Regulation by Cyclic Amp
| Professor Mark Girolami | | Tim Palmer |Regulation of the immune/inflammatory responses by interleukin-6 (IL-6)-family cytokines is dictated by the interplay of multiple cytokine-activated signalling cascades and inhibitory regulators designed to prevent excessive receptor activation that can result in disease. The situation is further complicated by the observation that cytokine-activated signalling cascades are negatively controlled by distinct signalling modules such as those initiated by the prototypical intracellular messenger cyclic AMP. Despite its significance, the extensive level of cross-talk observed has not been integrated into coherent models of IL-6 receptor signalling and its regulation.