<XML><RECORDS><RECORD><REFERENCE_TYPE>0</REFERENCE_TYPE><REFNUM>8902</REFNUM><AUTHORS><AUTHOR>Downie,J.</AUTHOR><AUTHOR>Mao,Z.</AUTHOR><AUTHOR>Lo,T.W.R.</AUTHOR><AUTHOR>Barry,S.</AUTHOR><AUTHOR>Bock,M.</AUTHOR><AUTHOR>Siebert,J.P.</AUTHOR><AUTHOR>McConnachie,A.</AUTHOR><AUTHOR>Yap,C.</AUTHOR><AUTHOR>Bowman,A.</AUTHOR><AUTHOR>Ayoub,A.</AUTHOR></AUTHORS><YEAR>2008</YEAR><TITLE>DOUBLE-BLIND, CLINICAL EVALUATION OF FACIAL AUGMENTATION TREATMENTS: A COMPARISON OF PRI 1, PRI 2, ZYPLAST(r) AND PERLANE(r)</TITLE><PLACE_PUBLISHED>Journal of Plastic, Reconstructive & Aesthetic Surgery</PLACE_PUBLISHED><PUBLISHER>N/A</PUBLISHER><LABEL>Downie:2008:8902</LABEL><ABSTRACT>BACKGROUND: Facial wrinkles are caused by weakening of the natural sub-dermal collagen support layer. Dermal fillers can be used to treat deeper wrinkles, and this double-blind, randomised, single-centre study compared 4 fillers: PRI 1 and PRI 2 (porcine collagen), Zyplast® (purified bovine collagen) and Perlane® (cross-linked hyaluronic acid gel). METHODS: 79 females (aged 25-55 years) with facial wrinkles in the upper lip line border were randomised to PRI 1 (19 patients), PRI 2 (19 patients), Perlane® (23 patients), Zyplast® (18 patients). Patients were assessed at 1 week and at 1, 3, 6, 9 and 12 months post-treatment using a wrinkle scale (using 2D images) and by mathematically derived facial volume changes using (3D stereophotogrammetry). RESULTS: All treatments produced larger, less wrinkled, more prominent lips. PRI 1, PRI 2 and Zyplast® showed similar lip volume gains, with Perlane® showing the greatest upper lip volume increase. All treatments were comparable for rates of decrease in upper lip volume post-treatment however perlane maintained higher lip volume gains at each time point. Investigators indicated PRI 1 was significantly easier to deliver than Zyplast®. Patient satisfaction scores were similar at treatment, though there was a trend towards greater dissatisfaction for PRI 1 and PRI 2 at month 9 (p=0.052). Treatment was well-tolerated, with ‘cold sore’ being the most common adverse event. CONCLUSIONS: Results showed that PRI 1 and PRI 2 were comparable to Perlane® and Zyplast® for use as dermal fillers. Further methodologically rigorous studies are required to establish the performance of dermal fillers and patient acceptability. We propose the utilisation of stereophotogrammetry of assessment of volume changes.</ABSTRACT><NOTES>in press</NOTES></RECORD></RECORDS></XML>